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Also, kidneys in adult IGF-1 -/- mice are less than half the size compared to wild-type animals, and, IGF-1R -/- mice displayed severe intrauterine growth retardation and died immediately after birth, presenting hypoplastic organs including the kidneys [27, 125, 126]

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SOD1 was the first gene linked to ALS (Rosen et al., 1993), thus there has been intensive research into pathogenic mechanisms associated with mutant SOD1 (Rosen et al., 1993)