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Interestingly, in the DRG from FRDA patients, the expression of FPN is exclusive to satellite cells (Koeppen et al., 2009), probably as a response to the iron release from DRG neurons to these cells (Koeppen et al., 2016)

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Therefore, one of the main methods of desensitizing cells to ferroptosis may be inhibiting ACSL4 expression, which is controlled by a number of signalling pathways [35, 36].Conversely, increased ACSL4 expression may contribute to ferroptosis in various pathophysiological settings [37, 38]

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