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Hydroquinone, when used in unregulated concentrations without medical supervision, causes ochronosis, a permanent bluish-black skin discolouration, and rebound hyperpigmentation that is darker than the original condition when use is discontinued

Disparate results are likely due to study design issues, often linked to a lack of understanding of vitamin C pharmacokinetics and requirements (19, 20)

Results MANF is specifically upregulated in human ICC tissues and positively correlates with the clinicopathological features To initially investigate the role of MANF in ICC, we collected paraffin sections from 78 patients and frozen samples from 6 patients with simple ICC, four samples with both ICC and HCC, and serum from 23 ICC patients and 25 healthy individuals

By encouraging iron apoptosis through the increase of ER stress and the production of PEBP1/15-LO, DHA can limit the progression of HCC (129, 130)