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Energy Expenditure and Thermogenesis Research Research applications extend to metabolic rate investigation: Oxygen Consumption: Measurement of whole-body or tissue-specific respiration rates Mitochondrial Function: Studies on oxidative phosphorylation, ATP production, membrane potential Mitochondrial Biogenesis: Investigation of mitochondrial mass, mtDNA copy number, biogenesis gene expression Brown Adipose Tissue: Research on BAT activation, UCP1 expression, thermogenic capacity Physical Activity: Examination of spontaneous activity and exercise performance Substrate Oxidation: Studies on fatty acid vs

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This hypothesis is supported by initial experimental evaluation of ADO in paired blood and BM plasma samples from MM patients, obtained before and after treatment with daratumumab (in collaboration with Dr