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Mitochondria are the primary intracellular site of oxygen consumption and the major source of ROS, most of them originating from the ETC

181 Further, the activity of G6PD is also repressed by aspirin casing acetylation of G6PD to decrease the activity of G6PD and the generation of NADPH, and by RRx-001, a novel clinical-stage chemosensitizer and radiosensitizer, which exerts antiproliferative effects in human tumor cells

Clinical trials are essential before new drugs enter the market, and some drugs may not play a better role in humans or may be restricted as non-negligible side effects

Neurotherapeutics 17 , 17961812 (2020)