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Yet, as with NRF2, tumor contexts complicate interpretation: HO-1 is overexpressed in some cancers, including HCC, where it actively supports tumor progression by enhancing survival via mechanisms such as increasing cancer cell proliferation, conferring resistance to chemo- and radiotherapy, and promoting angiogenesis, as indicated by its strong correlation with VEGF expression and microvascular invasion

(2021) investigated kynurenine metabolites in plasma from 49 ME/CFS patients (meeting CDC-1994 criteria), 57 FM patients, and 54 HC (Groven et al., 2021), while Schwarz et al

10.1016/j.jep.2023.116888 J

The human body produces free radicals, which antioxidants help to break down to prevent cellular damage [5]