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In conditions like Alzheimers, reduced GPx activity permits reactive oxygen species to accumulate, leading to protein misfolding and neuronal death

Phull AR, Majid M, Haq IU, Khan MR, Kim SJ

NS5A and core proteins trigger oxidative stress-mediated Ca 2+ homeostasis alterations in human hepatocyte-derived cells, thereby enhancing HCV-induced pathogenesis 110