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Nevertheless, an ROS independent mechanism mediated by iron has recently been proposed for FRDA neurodegeneration

Hydrogels applied in the delivery of peptides for IBD Compared to NPs, hydrogels offer several distinct advantages, including superior biocompatibility, strong mucosal adhesion, environment-responsive release kinetics, versatile chemical tunability, customizable formulations, and sustained-release capabilities

Tringali et al., 2012)

The study showed that rutin can target the Cys 151 of Keap1, and form an adduct with Keap1 which results in Nrf2 activation and upregulation of glutamate cysteine ligase, a glutathione biosynthesis rate-limiting enzyme which plays an important role in the endogenous antioxidant system (Sthijns et al., 2017)