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The most plausible explanation is that the non-responders used incorrect administration of the nasal drops

HGF is a potent neurotrophic factor that promotes neurogenesis and has been shown to have neuroprotective effects in neurodegenerative diseases (reviewed in: 37 )

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doi: 10.1021/ja303280r 101 GuoQ.XuS.YangP.WangP.LuS.ShengD.et al