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This result suggests that increasing copy number was shown to be effective up to a certain limit of gene copy number

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Speake, J.R., McCann, T.J

While intra-tumor light delivery (interstitial PDT, I-PDT) enables treatment of deeply seated tumors or tumors exceeding 10 mm in thickness, this approach necessitates percutaneous or intraoperative implantation of optical fibers into tumor cores, which may lead to procedure-related complications including hemorrhage, infection, and tumor cell seeding along needle tracts