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Ethics declarations Ethics approval and consent to participate The study protocol was approved by the ethics committee of Guilan University of Medical Sciences (IR.GUMS.REC.1400.197) in accordance with the World Medical Associations code of ethics (Declaration of Helsinki, revised in Brazil 2013), and registered at an ICMJE and WHO recognized registry of clinical trials (www.irct.ir) at 28/08/2021 (registration number: IRCT20200920048782N1)

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PROFHILO STRUCTURA [4.5% 22.5 mg (H-HA) + 22.5 mg (L-HA)/1 ml Hyaluronic acid sodium salt and 4.5% 45 mg (H-HA) + 45 mg (L-HA)/2 ml Hyaluronic acid sodium salt], injection gel in a single use sterile prefilled syringe