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Prooxidant properties of naringenin may cause cytotoxicity to various cancer cell lines, apoptosis, and activation of one of the Mitogen-activated protein kinases, ASK1 resulting in apoptosis by ROS-mediated activation of ERK1/2 (Park et al

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ii) Utilizing the steric hindrance conferred by dimerization reduces protease access to the active site and significantly improving stability against proteases 49,50

In this context, disruption of temporal coordination, rather than hormone abundance alone, may limit effective engagement of melatonin-dependent immunoregulatory pathways