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Description

The resulting bzr1-1D-GR and bzr1-1DdEAR-GR were inserted into pENTR/SD/D-TOPO vector (Invitrogen) and subcloned into gateway compatible pEarleyGate101 vector for transformation into Arabidopsis

154 Additionally, structural optimization of non-bile acid FXR agonists led to the development of compound 42 as an FXR agonist with high efficiency and selectivity for alleviating MASH