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Excess iron content was detected in lysosomes of proximal tubule epithelial cells, which could induce renal dysfunction in DKD patients and mice[80]

In the following sections we briefly discuss the identified proteins that were found to be altered upon neuronal tianma stimulation and we hypothesize potential applications of tianma that may emerge from our data obtained: Increased neuro-protective protein levels in differentiated neuronal N2a cells upon tianma activation Nxn : Nucleoredoxin is a novel thioredoxin family member that is involved in cell growth and differentiation where it sustains Wnt/-catenin signalling by retaining a pool of inactive dishevelled protein [27-29]