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Compared with existing iron-chelating agents, they are very safe and inexpensive

While this process temporarily alleviates proteotoxic stress in the parent cells, these encapsulated dangerous molecules rapidly transform into high-concentration extracellular signaling sources, transmitting injury signals to neighboring alveolar epithelial and endothelial cells, thereby triggering a more extensive inflammatory cascade (26)

However, there is a fair amount of genetic variation within and between tomato species, which could be used to increase tomato cultivars' chilling tolerance

for example, a modified Mediterranean-type intervention in mild cognitive impairment (MCI) increased microbiome diversity and reduced inflammatory markers [232, 234, 235]