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Following the discovery of the first m 6 A methylation transferasemethyltransferase-like 3 (METTL3)subsequent research has progressively revealed several associated enzymes including writers, erasers, and readers. These enzymes work in both temporal and spatial coordination to dynamically and reversibly regulate m 6 A methylation of RNAs, thereby playing a crucial role in a variety of biological processes [27] (Fig

Mitochondrial signals that activate nuclear responses are called retrograde signals. Their function is to improve energy efficiency, monitor the cell cycle, respond to cellular stress, and eliminate dysfunctional organelles, among others (Yang and Kim, 2019)

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