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In addition, intracellular scaffold proteins interface with the actin cytoskeleton, linking transmembrane tight junction proteins to the cytoskeleton and subsequently acting as a molecular target for tight junction dysregulation in various pathways, including the Zot and zonulin pathways, which both involve the dysregulation of tight junction proteins to induce alterations in intestinal permeability (7, 1115)

Clinical trials have shown that higher doses often lead to greater weight loss, but they may also increase side effects

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Increased Tgf-beta1 production by rat osteoblasts in the presence of PepGen P-15 in vitro