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Preclinical studies show that combining decitabine with histone deacetylase inhibitors (e.g., sodium butyrate) synergistically upregulates NIS mRNA expression (by up to 1600-fold) and significantly increases iodine uptake (9-fold in DRO cells, 8-fold in 2-7 cells) [95], supporting epigenetic combination therapy as a viable strategy to overcome resistance