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Stimuli-responsive nanocarriers can be designed to release therapeutic agents in response to specific pH conditions, enzymatic activity, or pathogen-associated molecular patterns characteristic of individual patient disease states [94, 101, 102]

Meanwhile, due to the presence of vascular lesions, neurological dysfunction, and repeated treatment failures in ulcerative wounds, DFU have also emerged as a primary cause of non-traumatic lower limb amputation [5]

Abraxane, formulated with albumin-bound nanoparticles and the cancer chemotherapy agent paclitaxel, is a nanomedicine within this size range that has been effective in breast cancer treatments [30,31,32]

The emerging role of furin in neurodegenerative and neuropsychiatric diseases