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The latter can be reduced by thioredoxin (Trx) 2, which is further reduced by thioredoxin reductase [28]

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The major limitations of these studies included were small sample size consisting of healthy Volunteers, extremely short study periods with an even shorter follow- up and Lack of measurement of Blood Levels of Glutathione.The investigators also did not estimate baseline or post- treatment renal or thyroid function of the Subjects, both of which were reported to be adversely affected by IV glutathione