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The success of autophagy-modulating therapies will rely not only on their mechanistic efficacy in preclinical models but also on their capacity to achieve sustained, tolerable, and reproducible effects in heterogeneous patient populations

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1 Introduction Osteoporosis is a common skeletal condition marked by a decrease in bone mass and the degradation of the microstructure of bone tissue, resulting in increased fragility of bones and an elevated likelihood of fractures ( In recent times, ferroptosis, an innovative type of cellular demise, has attracted considerable interest within the domain of bone metabolism

Of note, pharmacologically induced PFC NMDAR hypofunction leads to increased oscillations [99] while genetic deletion of NMDAR1 subunits in pyramidal neurons increases oscillations, cell excitability and sEPSC frequency [100], similar to the present data