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In supplement formulation, L-Carnitine is not a single material choice: L-carnitine base, L-carnitine L-tartrate, acetil-L-carnitina, propionyl-L-carnitine, and fumarate forms differ in target use case, taste, powder behavior, hygroscopicity, dose size, and capsule-filling feasibility

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All these alterations contribute not only to the weakening of the response to conventional therapy in this population, but also to chronotherapy, which presupposes a physiological rhythmicity that is not observed in these patients, particularly in the presence of comorbidities, polypharmacy, or sleep disorders (Lvi et al., 2010