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doi: 10.1093/jxb/erj184 95 PentermanJ.AboR

Lactate, a glycolytic metabolite and a regulator via Kla influences histone and non-histone functions to maintain a balance between immunosuppression and immune activation

Burton et al., Advances in Immunology 57:191-280 (1994)

For example, the TNFRSF1A polymorphism explains 0.06% of the genetic risk for AS, and yet tumor necrosis factor (TNF) inhibition therapy is highly effective in the treatment of this disease