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CD38 is an ectoenzyme (NADase) whose expression increases with age and chronic inflammation

In the proximal small intestine, luminal absorption of low Ca 2+ concentrations involve mainly the transcellular route (vitamin D-dependent) and for high concentrations, the paracellular passive route (vitamin D-independent) is the predominant source for calcium absorption

This can lead to a loss of confidence in clinical decision support tools that incorporate DDI databases, and lead to different treatment decisions, depending on which database the healthcare professional relies on

Therefore, you will need regular eye tests if you are taking this drug especially if youve been taking it for five years or more