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Specifically, SSZ treatment enhanced locomotor activity, ameliorated gait abnormalities, and improved cognitive function compared to untreated AD rats

Pharmacol Rev 65(1):315499 Wilson ID, Nicholson JK (2014) The modulation of drug efficacy and toxicity by the gut microbiome

The body has fully adapted to that concentration, and adding more will produce a predictable increase rather than an unpredictable spike