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In rats with STZ-induced DN, podocyte-specific mRNA levels, as well as fibronectin and collagen a5(IV) protein levels, are increased, which correlate with increased 12-LOX mRNA and protein expression, increased p38 mitogen-activated protein kinase (MAPK) mRNA expression, and p38 MAPK protein activation (Ma et al., 2005

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It happens during things that push on your belly and bladder, like coughing, laughing, sneezing, or lifting something heavy

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