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Li et al observed that endothelial cell pyroptosis is the dominant form of cell death in the initial phases of DMED development [89], and suppressing NOD-like receptor thermal protein domain associated protein 3 expression can significantly reduce pyroptotic activity in diabetic penile tissue of rats, enhancing the vascular endothelial function [91]

Protein density was measured by a Bio-Rad XRS chemiluminescence detection system (Bio-Rad, USA)

While TB-500's safety profile is generally favorable, long-term continuous use of any peptide has limited data