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Furthermore, melatonin can act on MT1 and MT2 on the surface of human monocyte U937 cells, stimulating intracellular ROS production

Oxidative stress leads to sperm dysfunction ( Genetic factors Genetic factors play an important role in the most serious spermatogenic disorders, such as severe oligozoospermia or azoospermia ( In infertile men, the incidence of chromosomal abnormalities has been reported to range from 5 to 15%, indicating that these abnormalities lead to non-obstructive azoospermia (NOA) ( AZF a (792 kb), AZF b (6.2 Mb), and AZF c (4.5 Mb) which contain several genes responsible for male fertility ( AZF c region containing eight gene families causes progressive deterioration of spermatogenesis and, consequently, azoospermia eventually leads to phenotypic changes in infertile men ( Spermatogenesis is thought to be regulated by as many as 2,000 genes, of which 600900 genes seem to be expressed only in the male reproductive line

Although ROS are beneficial for host defense against pathogens, their accumulation damages cells and disrupts immune system homeostasis (83)

Tot slot beschermt zink celmembranen tegen ijzerafhankelijke vetzuuroxidatie (Zago, et al., 2000)