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Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase pho-sphatase activity in human skeletal muscle, J Clin Invest 85(2) 1990 476 81.10.1172/JCI114462

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Also preferably, the sum of interconnected biodegradable functional groups and permanent linkages to conjugate functional groups carrying ligands or chelating groups or ion exchange groups, or optionally spacer molecules, or blocking groups is equal to or greater than 16, preferred 20-40, more preferred 28-32 and most preferred 30-32