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1014 It inhibits human SIRT1 and SIRT2 with IC 50 values of 56 and 59 M in vitro, respectively, 240 and reduces the expression of poorly differentiated markers -fetoprotein and glypican, and impairs cell migration in a dose-dependent manner

687 During targeted drug therapy, DNA methylation can also affect cellular viability, giving rise to resistance to targeted therapy

Lee D, Huntoon K, Wang Y, Kang M, Lu Y, Jeong SD, Link TM, Gallup TD, Qie Y, Li X, Dong S, Schrank BR, Grippin AJ, Antony A, Ha J, Chang M, An Y, Wang L, Jiang D, Li J, Koong AC , Tainer JA, Jiang W, Kim BYS

Cultured rabbit lens epithelial cells have also been used to investigate the effects of UV-A and/or UV-B (201206), as well as the efficacy of UV blocking contact lenses (207, 208)