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In fact, a randomized, controlled trial published in Psychoneuroendocrinology found that supplementation with 2.5 grams a day of long-chain omega3 fatty acids (EPA and DHA) for four months in 138 middle-aged, sedentary adults significantly reduced overall salivary cortisol (19 percent) and the proinflammatory marker IL6 (33 percent) during a standardized stress challenge

Key References Following are the most informative references cited in this paper, as determined by the authors

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CBD treatments for 48h lead to survivals (%) of 89.462.97, 78.662.512, 60.093.012, 53.15 2.849, 37.251.599 at 0.1, 0.3, 1, 3 and 10 M respectively (Fig 1A)