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FXN knock-in/knock-out (KIKO) mice exhibited hyperlipidemia, reduced energy expenditure and insulin sensitivity, and reduced thermogenic activities of brown adipose tissue

However, we do not fully understand why these aging hallmarks occur in the first place, and therefore there have been no proven solutions via human randomized clinical trials to improve or correct aging hallmarks in aging humans. The aging hallmarks that improved are mitochondrial dysfunction, altered intercellular communication, nutrient sensing, loss of proteostasis, genomic instability, cellular senescence and stem cell fatigue

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Shifts the oxygen-hemoglobin dissociation curve to the left (increased affinity of hemoglobin for oxygen, reduced offloading of oxygen to tissues)