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Abida, W

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Substances such as cytostatics, including N-mustard, diazobutane, diepoxybutane, methanesulfonic acid, cyclophosphamide, busulfan, melphalan, and cisplatin are called direct working alkylating substances because they either get bound themselves in toto at the nucleophilic site or work by transferring alkyl groups on to SH , NH 2 , COOH , and phosphate groups

352 In the context of FHM type 2 deficient NKA not only results in the impaired K + buffering but is also linked to down-regulation of astrocytic EAAT2 glutamate transporters, which dives pathophysiology of this form of migraine