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Therefore phase 3 clinical trials stipulated that high dose oral supplementation of CoQ10 did not produce significant advantages, potentially due to obstacles related to its bioavailibity, which limited its absorption in striatum and hinders its transport across the blood brain barrier [7]

* Correspondence: Yunqing Ban, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

10.1021/ar4002075 40 NguyenP

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