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For example, by decreasing the affinity of a T cell receptor for an antigen (which a TCR binds in conjunction with an MHC molecule, i.e., the MHC "presents" the antigen to the TCR), the methods of the invention can generate a non-autoreactive variant of an autoreactive TCR

10.31083/j.rcm230517839077615 204 Chen Y, Wu Y, Chu X, et al

J Neurochemistry 80:780787 Low JG, Ng JHJ, Ong EZ, Kalimuddin S, Wijaya L, Chan YFZ, Ng DHL, Tan H-C, Baglody A, Chionh Y-H et al (2020) Phase 1 trial of a therapeutic antiyellow fever virus human antibody

Because neither LDs nor mitochondria integrate into the classical vesicular transport pathways, non-vesicular lipid transfer between them and with the ER relies on membrane contact sites (MCS), zones of close apposition between organelles without membrane fusion (Scorrano et al