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doi: 10.3390/brainsci10090631 45 BrownSJHuangXFNewellKA

HallDAVoigtRMCantu-JunglesTMHamakerBEngenPAShaikhMet al

Polyphenols in Human Health and Disease , 793-818

The formation of metal-flavonoid complexes significantly enhances their bioavailability, positioning these compounds as promising candidates for next-generation therapeutics ( Ehretia tinifolia extract (ETME) counteracts this response by activating the protective Nrf2/HO-1 pathway while suppressing NF-B/MAPK-mediated inflammation