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S.MavaddatH.PeyrovinasabA.Ghasemi ZargarS.Sirous KabiriS.et al (2024)

The symptoms of CIPN are primarily felt in the hands and feet with some combination of numbness, tingling, shooting or stabbing pain, burning pain, cramping, and hypersensitivity to cold temperatures (e.g., cold weather, touching something cold) (Staff et al., 2017

Their antioxidant, immunomodulatory, and endothelial-protective activities position them ideally for this

For instance, the release of Smac/Diablo into the cytosol ensures the efficiency of caspase 3 in proteolyzing target proteins through inhibition of inhibitor of apoptosis proteins (IAPs)