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Seal cells dampen inflammatory signaling throughout hypoxia exposure Our data suggest continued regulation of inflammatory signaling in seal endothelial cells across 6 h of hypoxia exposure

Large EVs have the capacity to enclose whole mitochondria, in contrast to small EVs, which mainly contain mtDNA and mitochondrial proteins

However, for these systemic applications, high doses are often required to overcome rapid enzymatic degradation and achieve therapeutic tissue concentrations