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Furthermore, PX-12 regulates metastasis of colon cancer cells by diminishing the expression of vascular endothelial growth factor and attenuating hypoxia-inducible factor 1 subunit alpha (HIF1A) levels [227]

Sala M, Diab R, Elaissari A, Fessi H

[107] also found that anti-MDA antibodies have a role in accelerating bone erosion in RA via inducing glycolysis and lipid biosynthesis of osteoclasts

Ethnicity imposes greater risk for development of neuropathy following vincristine, which is metabolized via the cytochrome P450 (CYP) 3A4 and CYP3A5 pathways (Dennison et al., 2007)