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the antibody or ADC of embodiment 72 wherein the antibody or ADC further comprises a VL CDR3 having an amino acid sequence of a VL CDR3 of 12G3H11, B233, B208, B210, G5, 10C12, 4H5, 10G9, 3F2, 1C1, 1F12, 1H3, 1D3, 2B12, or 5A8

This is contrary to Mohan et al.s earlier report that suggested WA might inhibit NFB activity by impairing IB degradation and ubiquitination [98]

Marked upregulation of the Hippo pathway transcriptional activator, TAZ, is evident in liver samples from NASH patients, but not from patients with simple steatosis (149)

TNF- activates multiple signaling pathways through binding to its receptors (TNFR1 and TNFR2), inducing the release of inflammatory mediators, cell proliferation, apoptosis, and immune cell recruitment, ultimately leading to chronic intestinal inflammation