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While this treatment approach is sufficient to correct for peripheral symptoms such as anemia, the accompanying neurological defects are not easily addressed since patients require supraphysiological folate concentrations in blood to be able to increase CSF folate

Chng, Aileen Wee, Pierre Bedossa, Rui Huang, Jian Wang, Lai Wei, Hong You, Huiying Rao Diagnostics.2024

Baumann N, Pham-Dinh D

The ROC curve features identified using PLS-DA and cross-validation (CV) exhibited area under the curve (AUC) values ranging from 0.95 to 0.996, with confidence intervals (CI) of 0.818-1 and 0.975-1, respectively (Fig