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The mitochondria become sluggish, fragmented, and unable to meet the daily energy demands of the body, resulting in the debilitating, leaden fatigue that characterizes these conditions

4188-A CROSS TALK BETWEEN SIRT6 AND TGF-BETA SIGNALING MODULATE HUMAN NASH-HCC Xiyan Xiang 1 , Xiaochun Yang 1 , Krishanu Bhowmick 1 , Kazufumi Ohshiro 1 , Anil K Vegesna 1 and Lopa Mishra 1,2 , (1)The Institute for Bioelectronic Medicine, Feinstein Institutes for Medical Research, & Cold Spring Harbor Laboratory, Department of Medicine, Division of Gastroenterology and Hepatology, Northwell Health, Manhasset, New York, USA., (2)Center for Translational Medicine, Department of Surgery, the George Washington University, Washington, DC, USA., Washington, DC Background: NASH driven HCC is rising alarmingly in the US