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Since the MPOC platform provides a means to enforce metabolic patterns, it can be re-purposed to study metabolic diseases where one can pattern a tissue with increasing levels of metabolic deficiencies or disruptions

However, these effects were abolished upon the addition of the PGC-1 inhibitor SR-18292.To further investigate the role of irisin in mitochondrial function recovery, we used transmission electron microscopy to observe mitochondrial morphology under different treatment conditions

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