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Another potential problem of using senolytics is an acceleration of stem cell exhaustion. Without clearance of apoptotic bodies, secondary necrosis could result in the release of proinflammatory, danger-associated molecular patterns, further exacerbating systemic chronic inflammation

Yes, you may see an immediate difference registered on your scale, but this is likely just a short-term effect

Long-term safety and efficacy of subcutaneous tanezumab versus nonsteroidal antiinflammatory drugs for hip or knee osteoarthritis: a randomized trial

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