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This T3 reduction is hypothesized to mimic the physiological response seen during fasting or marked caloric restriction, while TSH remains stable because central feedback perceives the lower T3 as an adaptive, not a pathological, state

Endogenous Detoxification of Lipid Aldehydes and DR Cells have evolved a range of protective mechanisms that enable the rapid metabolism and detoxification of lipid aldehydes produced during lipid peroxidation reactions

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