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Reportedly, the blood concentration of pirfenidone 5-carboxy-pirfenidone metabolite excreted through the kidneys significantly increases in patients with severe renal impairment (area under the curve of mild, moderate, and severe renal impairment was 49.3, 100, and 168 mghr/L, respectively

doi: 10.1038/ki.1991.277

We thank Analytical & Testing Center of Huazhong University of Science and Technology for the technical support of confocal microscope data acquisition