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Description

Second, HIF-1 induces metallothionein-2A (MT2A) expression by direct binding to the hypoxia response element on its promoter

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Leptin resistance is a condition in which the body fails to respond adequately to leptins satiety-inducing, fat-burning signal

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2b,d).The increase in -glutamyl peptides (2AB and OA) in cysteine-limiting conditions in vivo is consistent with studies that show that GCLC can synthesize -glutamyl-2-aminobutyryl-glycine in a GSH-independent manner and prevents ferroptosis by lowering glutamate generated oxidative stress 20

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in an STZ-induced diabetes model in mice under triple blockade of FoxO1, Notch, and Tgf- (Du et al., 2022)

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