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Benzos enhance GABA A receptor activity by increasing the frequency of chloride channel opening, leading to CNS depression. They are first line for status epilepticus (e.g., lorazepam), used for anxiety, panic disorder, alcohol withdrawal Quantitative prediction of CYP3Amediated drugdrug interactions by correctly estimating fraction metabolized using human liver chimeric mice Miyake 2024 British Journal of Pharmacology Wiley Online Library does alprazolam increase glutathione Alprazolam exposure during adolescence induces long lasting dysregulation in reward sensitivity to morphine and Frontiers Midazolam Ameliorates Acute Liver Injury Induced by Carbon Tetrachloride via Enhancing Nrf2 Signaling Pathway
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