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The main mechanism of action of Phentermine/Topiramate extended release(ER) is possibly the alteration of various neurotransmitters, including inhibition of voltage-dependent sodium channels, glutamate receptors, and carbonic anhydrase as well as potentiation of -aminobutyrate activity (83).Two large randomized, double-blind, placebo-controlled trials took place (EQUIP and CONQUER) followed by a 2-year extension trial (SEQUEL)

those above 1000 Da absorb poorly without penetration enhancers such as cyclodextrins or bile salts

The monochlorobimane reagent was prepared by reconstitution in DMSO per manufacturers directions