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A 2014 follow-up study showed increased dendritic spine density in CA1 hippocampal neurons following chronic dihexa administration

Although any part of the nephron can be affected, proximal tubular epithelial cells (TECs) are particularly vulnerable because of their high metabolic rate and limited ability to produce energy without oxygen

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Many contain hydrophobic regions that readily bind to plastic surfaces, pulling active peptide out of solution and depositing it on the container walls